|(4aR,10bR)-4-丙基-3,4,4a,10b-四氢-2H,5H-苯并吡喃并[4,3-b][1,4]恶嗪-9-醇盐酸盐|CsnPharm

CAS No.: 300576-59-4

(4aR,10bR)-4-Propyl-3,4,4a,10b-tetrahydro-2H,5H-chromeno[4,3-b][1,4]oxazin-9-ol hydrochloride Catalog No. CSN22612

Synonyms: (+)-PD 128970 HCl

(+)-PD 128,907 HCl is an agonist of D3 dopamine receptor with Ki of 2.3 nM.

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实验方案

技术信息

生物活性

描述The D3 receptor is thought to play a role in reinforcement pathways because it is expressed in high levels within the mesolimbic dopaminergic system and, more specifically, the nucleus accumbens shell. (+)-PD 128907 HCl is a dopaminergic agonist with a range of in vitro D3 selectivity^[1]. Low doses of (+)-PD 128907 reduced spontaneous locomotor activity in the rat (ED₅₀ = 13 ± 3 μg/kg, s.c.) a response which was comparable with the non-selective D2,3 receptor agonist apomorphine (ED₅₀ = 13 ± 1.6 μg/kg, s.c.). In addition, (+)-PD 128907 impaired prepulse inhibition of the acoustic startle response, with significant effects observed at doses of 30 μg/kg when appropriate prepulse intensities were used. Higher doses of (+)-PD 128907 HCl reversed gamma-butyrolactone-induced catecholamine synthesis (ED₅₀ = 95 ± 22 and 207 ± 37 μg/kg in accumbens and striatum respectively) and induced yawning (100-300 μg/kg), penile grooming (30-1000 μg/kg) and sniffing (> or = 300 μg/kg). In addition, the observation that (+)-PD 128907 disrupts prepulse inhibition, a phenomenon which is also impaired in schizophrenic subjects^[2].
参考文献

[1] Collins GT, Witkin JM, Newman AH, et al. Dopamine agonist-induced yawning in rats: a dopamine D3 receptor-mediated behavior. J Pharmacol Exp Ther. 2005;314(1):310‐319
[2] Bristow LJ, Cook GP, Gay JC, et al. The behavioural and neurochemical profile of the putative dopamine D3 receptor agonist, (+)-PD 128907, in the rat. Neuropharmacology. 1996;35(3):285‐294

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.4994 mL
- 17.4968 mL
- 34.9936 mL
- 5 mM
- 0.6999 mL
- 3.4994 mL
- 6.9987 mL
- 10 mM
- 0.3499 mL
- 1.7497 mL
- 3.4994 mL

技术信息

CAS号

300576-59-4

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C14H20ClNO3

运输

蓝冰

分子量

285.77

别名

(+)-PD 128970 HCl

溶解度

DMSO	175.0 mg/mL (612.4 mM)
Water	68.0 mg/mL (238.0 mM) warming

动物实验配方

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(4aR,10bR)-4-Propyl-3,4,4a,10b-tetrahydro-2H,5H-chromeno[4,3-b][1,4]oxazin-9-ol hydrochloride Catalog No. CSN22612

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